1st International Symposium in O3 Ozone Applications
O3 Ozone in Medicine
October 31st to November 3rd 1990
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Abstracts
O3 Ozone as radiological contrast.
Ozone is a gas with comprises the parameters to he used as a radiological contrast, according to the experience obtained in experimental studies and clinical application.
The advantages offered by ozone as a radiological contrast allow it to be used in angiographies in patients allergic to iodine and when hepatopathies, nephropathies, heart insufficiencies or multiple mieloma are present, where the iodine contrast is forbidden.
Its low cost of obtainment and therapeutic properties, make it useful in every kind of patient submitted to an infradiaphragmatic angiography by digital substraction.
Among the restrictions for its use, we can point out its instability and the fact that it can only be used by means of an arterial catheterism.
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O3 Ozone therapy in the treatment of peyronie disease.
It is known as Plastic Induration of the Penis (PIP) or Peyronie disease, the fibrous plaque originated in the cavernous bodies of the penis as a consequence of a series of alterations of the fibroconnective tissue of not well precised etiology and which provokes a series of manifestations (objective and subjective) as pain and the curving of the penis during erection.
The purpose of this work was to evaluate the application of ozone therapy in a group of 25 patients who had not received previous treatment.
Infiltrations of ozone were made in the fibrous plaque of the penis in a dose of 0.1 mg, together with treatment of autohemotherapy (dose of 3 mg), 3 times a week until completing 15 sessions. At the end of it, the cycle was repeated.
The results obtained were: very good 3; good 12; satisfactory 7 ... and bad 3; according to the behavior of the fibrous plaque and clinical symptoms.
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O3 Ozone therapy in the demential stage of elderly people.
We studied a sample made up by 50 elderly patients with a previous diagnosis of dementia who were submitted to ozone therapy through different ways.
The therapy was effective in all types and degrees of dementia with recovery of psychic and motor validity, specially regarding to symptoms of degenerative nature.
The best results corresponded to endovenous application of ozone and rectal insufflation. Intramuscular injection was less effective. No adverse reactions to treatment were present.
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O3 Ozone acupuncture: Another means to study the disease.
Vuvantuan J. Medical International Society of Acupuncture and Stimulating therapy, France.
Ozone is before everything oxygen, and even super-oxygen, as it possesses 3 atoms, instead of two. Its therapeutic effects are: anti-microbial, anti-toxical, anti-oxidating and general revitalizer. It also contributes with negative ions, with beneficial effects upon the body: anti-stress, anti-spasaodic, tranquilizer, healing, anti-allergic.
Acupuncture, on the other hand, considers man under the energetic aspect. This therapeutic study consisted of injecting subcutaneously between 5 and 10 mL of ozone in the acupuncture points, making like this a logical synthesis of these 2 techniques.
Due to the rational choice of the acupuncture, depending on the disease of the patient, the ozone effect is multiplied twice or thrice, since the indispensable reaches its due point.
It is a therapy deprived of side effects, at the same time natural, because it goes toward an universal constituent to life: oxygen, and a sweet and ancestral technique: acupuncture. Its field of action is constantly growing and it is a technique with a great future.
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O3 Ozone therapy in the treatment of vertigo.
In this preliminary study and elemental diagnostic evaluation of 6 patients suffering from vertigo was performed by means of otoneurological tests; audiometry; x rays of mastoids, skull and cervical spine; serum immune globuline E; doppler of the vertebro basilar root as well as a complete ophthalmologic test. These patients were submitted to ozone therapy (autohemotherapy). In the sixth session the symptoms started to disappear.
At the end of the treatment (fifteenth session), in half of the patients the symptoms decreased and in the rest disappeared. These results showed the treatment is suitable for the disease.
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O3 Ozone therapy in hypoxic states.
Peretyagin S.P., Boyarinov G.A., Zelenov D.H., Kontorshchikova K.N., Monahov A.N., Haksimov G.A., Srnirnov V.P., Yakovleva E.I., Balandina M.V., Koksharov I.A., Krivatkin S.L., Tarasova A.I., Rakov V.G. and Hikltia G.V. - Gorky Medical Institute, USSR.
Experimental and clinical investigations have shown the activation of biological oxidation under direct dosed ozone influence upon blood in the presence of hypoxia in the whole organism and ischemia in the organ and system levels. This influence is accomplished by various ways.
One of them consists in the stimulation of the antioxidative defense system. Increase of superoxide dehydrogenase and catalase activity. Conformational reconstruction of proteins and lipids due to aminoacid residues oxidation and selective electrophylic unsaturated lipid acid reactions also takes place.
An important role play the respiratory chain high activity, as well as glucose-6-phosphate and lactate dehydrogenase against the levels in the activity of the pentose phosphate path of glucose oxidation.
In addition, intensification of lactate and pyruvate utilization. Increase of phosphatose acid, adenosin di- and triphosphates levels along with the speed of their usage were registered. Finally it resulted in stimulation of biologically active substances, production and an intensification of detoxifying mechanisms.
Ozone therapy ensures more adequate vital activity also by means of positive indirect influence on the cardiovascular, respiratory and excretory systems, that is confirmed by a number of electrophysiological, morphohystochemical and ultrastructural data.
Taking into account the revealed mechanisms of ozone action. Its antimicrobial and inmunomodulating influence, clinical research has been carried out. The efficacy of ozone therapy was studied in cardiovascular and traumatic patients as well as in obstetrical and dermatologlcal practices.
Our data testify that it is necessary to extend the sphere of this perspective method of application.
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Evaluation of the treatment with O3 ozone in patients with retinitis pigmentosa.
Fifty patients complaining about this disease were studied. All of them were treated with ozone during 15 sessions by autohemotherapy. No other therapy was associated. At the end of the treatment a second perimetry was performed to every patient, under the same circumstances and with the same equipment and personnel than the first one.
A good campimetric improvement was obtained. The satisfactory results encourage to recommend its use (O3 ozone) in patients affected by Retinitis Pigmentosa.
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O3 Ozone therapy in childrens with retinitis pigmentosa.
The ozone therapy is used successfully at present for the treatment of Retinitis Pigmentosa.
Due to the effectiveness shown in grown-up patients, as well as the absence of adverse sideeffects. It was applied to 50 children carriers of the disease. The satisfactory results achieved are demonstrated by perimetry and handwriting quality.
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Retinitis pigmentosa in children and adolescents. Writing after O3 ozone therapy.
Children and adolescents, with a diagnosis of Retinitis Pigmentosa, who received treatment with ozone, in a relatively short time, (one month as an average), refer remarkable clinical improvement, in 90 % of cases.
The patients referred that, after the treatment, they were able to see more and better (with greater clearness and amplitude), they did not stumble at night and could play in the street.
It is almost constant the reference to the loss or decrease of the fright to darkness, anxiety and the improvement in their mood. They could throw and catch a ball. The objective improvement was observed in their writing (the second copy was obtained between 1 and 3 months after ozone therapy), after the treatment it was more clear, uniform and legible in most of cases.
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Analysis of sanguineous biochemistry in patients with retinitis pigmentosa before and after the treatment with O3 ozone by autohemotherapy.
With the aim to deepen and rule out undesired side effects due to application of ozone therapy by autohemotherapy. It was performed this research, focused towards the study of possible modifications of different biochemical parameters in patients after such treatment.
Forty patients who received ozone daily until completing 15 sessions were studied, measuring the following parameters: creatinine-phospho-quinase, urea, creatinine, lactate-dehydrogenase, high density lipoproteins, cholesterol, triglycerides, hepatic enzymes (TCP, TGO, gGT), bilirrubine, uric acid, alkaline-phosphase, proteins, calcium, phosphorus, hemoglobin, hematocrites, red and white cells and blood platelets.
In most of the biochemical parameters studied, no significant differences were found between the values at the beginning and at the end of treatment.
Related to calcium and urea a significant increase was found, but both initial and final values are within the normal range. Decreases statistically significant in triglycerides and cholesterol towards normal values and increase in hemoglobin were found.
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Endovenous O3 ozone therapy and blood lipids in arteritic and retinitis pigmentosa patients.
Present study was performed with the aim to assess the effect of ozone therapy through autohemotherapy, on the metabolism of lipids in patients with vascular disorders. Plasmatic levels of total cholesterol were measured, as well as HDL cholesterol, LDL cholesterol, apo B and triglycerides, before, during and after 15 sessions of treatment, with 5 mg of ozone.
In arteritic patients a decrease of total cholesterol from 3.2 up to 21.5 %, (mean value 11.8 %) referred to the initial value was found. The HDL did not suffer any change and the apo B showed slight decrease of 7.9 %.
The triglycerides remarkably decreased from 21.9 to 67.3 % (mean value 46.1). In patients with Retinitis Pigmentosa, it was found remarkable average decrease of 14.8 % in cholesterol and 49.5 % in triglycerides, both referred to initial values.
Data suggest, endovenous ozone therapy, remarkably stimulates the metabolism of lipids in these patients. At the same time, new therapeutic possibilities are open for hiperlipemia treatment.
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O3 Ozone therapy in optical nerve lesions.
Optical atrophy is one of the main causes of blindness in world. As part of the Central Nervous System the optical nerve has very few possibilities for regeneration. Among the factors, which can facilitate a certain degree of neuroplasticity of this structure is ozone therapy.
Results of ozone therapy (autohemotherapy), applied to 10 patients, who had different degrees of optical atrophy from several etiologies, are presented.
In 8 patients an improvement in vision sharpness or visual field were observed.
Two cases, which had hereditary optical atrophy did not improved. The results are discussed taking into account the different etiologies and affectation degrees.
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Post traumatic cortical atrophy treated with O3 ozone therapy.
The cranial encephalic traumatisms constitute one of the most frequent causes of death and invalidating lesions in the modern age. There are many treatments applied to achieve a correct rehabilitation and incorporation to the society of these patients who are still able to work.
The results obtained in a patient with inferior altitudinal hemianopsy post-cranial trauma of 2 years of evolution, who recovered great part of his lost sight and was able to incorporate to work are presented.
The authors discuss and explain the results by means of the colateralization phenomenon among other factors of neuroplasticity, which favor ozone therapy.
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O3 Ozone therapy in advanced chronic glaucoma.
The chronic glaucoma in advanced stage is a pathology regularly observed in ophthalmologic services. This disease has a bad prognosis with the treatments used so for. Bad irrigation is one of the factors, which worsen the symptoms.
The out-patients received the treatment usually employed in these cases, with a periodical control of several parameters, among them, the visual field. A group of these patients, chosen at random, received ozone therapy.
When ozone is applied as part of the treatment, there is an increase in the oxygenation of tissues and better evolution of these patients (enlargement of visual field) in comparison with the ones who did not received this treatment was proved.
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03 Ozone Therapy in simple chronic glaucoma.
25 patients with simple chronic glaucoma in different stages and tonometrically compensated were studied. They received ozone therapy, taking into account the therapeutic properties of this gas. In all these patients there was a circulatory deficit and dystrophic changes in the structures of the rear segment of the eye. Including the drainage system of the glomerular angle.
This group was measured, at the beginning and end of the treatment, the central and peripheral visual acuteness (visual field) and also were performed fondoscopy, gonloscopy, tonometry, silt lamp examination, study of the circulation of intraocular liquids (ionography) and electrophysiological study, which comprised electroencephalogram and evoked potentials.
Improvement in the visual acuteness and parameters, which measure the visual function was obtained.
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Application of O3 ozone in the treatment of ocular burns.
Ocular burns due to chemical reagents present high frequency in Cuba either due to acids or alkalis.
Taking into account the sequels they produce (loss of sight and aesthetics in patients), the treatment with ozone was evaluated as positive, stemming from its stimulating effect over the metabolisation and oxygen transportation to tissue level, together with its germicidal effect, what also favors the epithelisation and reduces the inflammatory process.
Daily application of ozone by subconjunctival injection around or on the lesions was evaluated.
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Application of O3 ozonized oil in keratitis of viral origin.
Keratitis is an inflammation of the cornea of diverse etiologies (viral, mycotic and bacterial). In Cuba it is frequent the care of this affection in emergency rooms and doctors' offices, and the viral one is the most common, in which it is observe a prolonged evolution in most of the cases.
Thirty patients affected by viral keratitis were treated by means of topic applications, 3 tiMes a day with ozonized oil. A control group treated with traditional methods (yodoxuridine, homatropine and anti-inflammatory drugs) was included.
It was observed that patients treated with ozonized oil showed clear improvement 48 hours after the treatment was started, and the cure was much more faster than in control group.
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Treatment of superficial keratitis with O3 ozonized oil collyrium.
The wide range of therapeutic possibilities of ozone, due to its germicidal nature, and stimulating effect upon the metabolisation processes of oxygen, allow its wider introduction to different branches of Medicine, specially those in which the results are not altogether satisfactory. Particularly in ophthalmology, the superficial keratifcis are difficult to treat and have along evolution.
Ozonized oil collyrium was used in this disease, comparing the results with a control group treated with conventional procedures. Patients were distributed at random, in both groups. Time necessary for healing was taken as measure of effectiveness. Regarding secondary reactions, the level of tolerance was considered as good.
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Application of O3 ozonized oil in epidemic hemorrhagic conjuntivitis and its complications.
A prospective study was carried out with a group of 100 patients suffering from epidemic hemorrhagic conjunctivitis and keratitis, as one of its complications. They were applied ozonized oil collyrium. They were all submitted, at the beginning and end of the treatment, to an ophthalmologic medical examination which, included a questionary, measurement of visual acuteness, fondoscopy, silt lamp examination and sodium fluoresceine stain at 2 %.
The advantages of such treatment are discussed, mainly shown by the fast clinical improvement of patients and its incorporation to work and social life and in second place for the simplicity of treatment.
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O3 Application of ozonized oil in patients with conjunctivitis.
The high incidence of cases with conjunctivitis and the germicidal effect of ozonized oil encouraged its application in the treatment for this disease. A study was performed in 130 patients affected by conjunctivitis from different etiologies, who were applied a drop of ozonized oil collyrium, twice a day.
Clear improvement was obtained twenty-four hours after beginning the treatment, with the disappearing of symptoms between the third and fourth days.
No undesired side effects were observed, what proves to be important if MB take into account that habitual medications are usually contraindicated in this disease, due to the complications, which usually arise.
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Application of O3 ozone therapy in the treatment of corneal ulcers and kerato-conjunctivitis.
A study comprising 5O carriers of kerato-conjunctivitis and corneal ulcers caused by infections of bacterial, viral and mycotic etiology, which were treated with ozonized oil collyrium is presented. Owing to its germicidal power.
It was decided to use this product in such pathologies, since they are occasionally resistant to conventional treatment and evolve towards destructive alterations of the ocular eyeball or corneal opacities with great vision distortion.
It was obtained clearly positive response to treatment applied every 2 hours. Likewise a remarkable improvement was also observed in cases early treated with no extensive lesions.
In corneal parenchynal deep lesions much better improvement is obtained and the cure is faster when ozonized oil is added to conventional treatment.
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Evaluation of O3 ozone therapy in human beings and animals infected with Giardia lamblia.
Taking into account the properties of ozone, as well as its stimulating action upon the metabolisation processes of oxygen and blood circulation, a study was carried out in Gerbils (meriones unguiculatus) infected by Giardia lambliaand after it, in a group of patients presenting reiterated therapeutic failures to different anti-giardia drugs habitually used.
In the case of animals, ozonized water was administered in doses of 0.0025 mg/kg weight, during 1; 5 and 10 days respectively.
Ozonized oil was applied intragastrically in doses of 18.3 mg/kg weight during 1; 2; 3; 4; 5 and 10 days. In humans, 30 mL of ozonized water with ozone dose of 0.02 mg/kg weight was administered, 4 times a day during twelve days.
Another group was treated with ozonized oil capsules with ozone dose of 0.18 mg/kg weight during 5 days, and sometimes even up to 10 days. 80 % of effectiveness was observed in animals treated with ozonized water during 5 days and 100 % of effectiveness in those treated with ozonized oil from the third day on.
In humans 97.5 % cured was obtained in those treated with ozonized water or ozonized oil. Results demonstrate ozone therapy constitutes a very effective therapy against this entity.
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O3 Ozonized oil as giardicide and its relation with the number of torfozoits in drainage.
The effectiveness of ozonized oil is confirmed in the treatment of symptomatic giardiasis in hospitalized patients. Its cure is related to the number of trofozoits in drainage and the use of better methods to verify its cure is discussed.
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Application of O3 ozonized oil in the treatment of Giardia lamblia in the municipality of Artemisa.
Hundred patients were assisted in the Parasitology service with the diagnonosis of Giardia lamblia.
The clinical manifestations were studied and it was found 86 % of cases presented some of following symptoms: abdomen pain, anorexia, diarrheas and diskinetic upsets. The diagnosis was confirmed through duodenal sampling and coproparasitological studies.
All patients received treatment with ozonized oil capsules. 87 % of them showed disappearing of symptoms and negativization of Giardia lamblia in tests performed.
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Comparative study with propoline and O3 ozonized oil in the treatment of giardiasis.
100 patients were studied with the diagnosis of giardiasis, resistant to previous treatment with Tinidazol, Metronidazol, Gabbroral and others. 50 patients were administered propoline, 30 drugs, 3 times a day during 10 d. A second group of 50 patients were treated with ozonized oil (OLEOZON®) in doses of 1 capsule of 1 mL daily, during 10 days.
The results showed a 38 % of negativization of the parasite in patients treated with propoline and 52 % in those who were administered ozonized oil. In every case the diagnosis was made by duodenal frotis.
The positive clinical response was also superior in the patients treated with ozonized oil.
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O3 Ozonized oil and its efficacy in epidermophitosis:
The climate, cleanliness, and type of footwear are the principal causes, which exert influence on the high incidence of this disease in our country. Due to the therapeutical properties of ozonized oil as the germicidal power, it was applied on those patients of the Pasteur Polyclinic suffering from epidermophitosis resistant to the habitual treatments.
The sample comprised 100 patients, 50 of them treated topically 3 tines a day with ozonized oil and the other 50 with the conventional methods. A 96 % of them were cured with the ozonized oil between the 10 and 15 days. In the control group, a 20 % was cured in 15 days.
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Treatment of epidermophitosis with topic O3 ozonized oil:
The results of the use of topic ozonized oil in epidermophitosis are presented. In Cuba this disease has a high incidence and tendency to the relapse, leading to long treatments, which are not always effective.
The clinical and mycological controls carried out to the sample analyzed, showed good results, thus proving the ozonized oil is a suitable therapeutical choice for the treatment of this disease.
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Treatment of onicomicosis with O3 ozonized oil:
A preliminary report about the results of the use of ozonized oil in the treatment of onicomicosis is presented, taking into account its antimicotic action, its good tolerance on the skin and the lack of side effects.
Onicomicosis constitute chronic diseases of the finger nails produced by yeast and filamental fungi, very resistant to treatments and very expensive and prolonged.
In the sample studied, the ozonized oil proved an efficacious remedy. Clinical and mycological controls were carried out.
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Therapy with O3 ozonized oil in ulcers in lower limbs.
The varicose ulcers, either associated to Diabetes Mellitus or not, have a frequent incidence. This disease becomes chronic very regularly and have a tendency to the relapse, creating an important social and medical problem and leading the patient to a total inability for a lifetime.
Due to the germicide nature of the ozonized oil, as well as its effect of stimulation in tissue regeneration. It was used in the treatment of this disease. A total of 120 patients suffering from ulcers in lower limbs were studied, 60 of then with ozonized oil and the other 60 by conventional methods.
A 100 % of patients treated with ozonized oil were cured between 15 and 30 days.
In control group a great majority needed a longer time to cure and even some of them did not achieve the complete healing. It is important to remark that with this treatment, hospitalization of patients diminish. Some cases were treated at home.
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Use of O3 ozonized oil in the treatment of ulcers in patients affected by leprosy.
Ulcerations and Plantar Perforating illness, are within the neurotrofic alterations in leprosy, the most frequent lesions observed in patients carriers of Hansen disease with important neurological affections and wrongly treated.
These lesions generally appear in the lower third of the legs and the sole of the feet in zones exposed to rubbing, presions and traumas. These are lesions of chronic and torpid evolution, very resistant to local conventional treatments. They turn complicated very frequently due to secondary infections, taking months arid even years to heal, and having the peculiarity of relapsing very easily.
The treatments in different places of the world, to achieve the cure of these lesions have been many, trying to shorten the time of evolution, the stay at hospitals and the cost of such treatments. The oils of vegetal source constitute ideal vehicles for the local therapy of ozone as ozonized oil.
In this preliminary study, was introduced the application of ozonized oil in the treatment of 30 patients carriers of Lepromatose Leprosy with neurotrophic ulcers In lower limbs with an evolution time between 6 months and more than 25 years, witnesses of no satisfactory results during the time they were under conventional treatment's.
The results obtained were: 4 patients cured and discharged from hospital; 15 patients with a satisfactory evolution and 13 patients were cut off from treatment.
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O3 Ozone therapy in hemorrhoids.
Twenty female patients carriers of hemorrhoids are presented, treated with ozonized vegetable oil in the anus.
The early disappearing of the pain while defecating and the pruritus was attained, as well as the sensation referred to by patients.
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Applications O3 ozonized oil in Herpes Simplex Labialis.
A preliminary experience, in the clinical application of a medication based on ozone and vegetable oil, in a group of 10 female patients carriers of simple labial herpes is presented.
An early disappearing of the lesion is observed.
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Use of O3 ozonized oil in the treatment of Herpes Simplex.
A study with 50 patients suffering from Herpes Simplex was carried out. They were applied ozonized oil topically.
The regression of local symptoms was achieved few hours after starting the treatment and local cure at the third day. The advantages in relation to other traditional treatments were proved, also its anti-viral effect, because the relapses of the disease was eliminated.
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Treatment of Simple Genital Herpes with O3 ozonized oil. Preliminary study.
A preliminary report about the results of the use of ozonized oil in the treatment of relapsing Simple Genital Herpes, stemming from its virucidal action, good tissue tolerance and absence of side effects, was presented.
The results of this therapeutical assay with 20 patients were satisfactory, since 8 patients had no more relapse in 9 months and from the rest who kept them, 8 were with longer intervals of time, 12 decreased the time of duration.
It can be considered that ozonized oil in the treatment of Herpes Simplex is a therapeutical choice, which should be investigated more deeply, though the results are good so far.
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Use of the O3 ozonized oil on patients with vulvogaginitis.
Trichomonas, Candida albicans and Gardenela vaginalis are present approximately in 97 % of vulvovaginitis. The application of ozonized oil was evaluated due to its fungicidal nature in the elimination of these types of microorganisms.
Sixty patients with vulvovaginitis were studied and were divided into 3 different groups, 30 were treated with ozonized sunflower oil, 20 with habitual methods (control) and 10 using as placebo the oil without ozonation. The criterion of cure was made by coloscopy.
A 100 % of cure was obtained between 5 and 7 days in patients treated with ozonized oil.
In control group, 20 % was cured between the 10 and 15 days. In placebo group there was an exacerbation of symptoms. In the group treated with ozonized oil, the elimination of itching was observed in 24 hours, as well as the pruritus, between 48 and 72 hours.
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Treatment with O3 ozone in gynecology.
The bactericidal and germicidal effect of ozone is known as of beginnings of the century, in the local treatment of wounds or infected lesions, in dermatitis, purulent eczemas, ulcers, etc.
Ozonized oil was used in the treatment of 20 patients who were carriers of infectious Leucorrea by fungi and/or bacteria. With these results a series of criteria of cure for this gynecological disease were established.
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Application of O3 ozonized oil as a treatment of vulvovaginitis in patients intolerant to carbohydrates.
Twelve female patients carriers of an intolerance to carbohydrates were studied. These patients had suffered from vulvovaginitis by Candida alblcans for years. They had been under different treatments without having been able to solve their pathology.
In spite of having normal levels of glycemy, these patients were indicated vaginal washes with ozonized oil during 5 days and to repeat this cycle two more times, after a rest of 2 days among them.
The results were the disappearing of vulvovaginitis and the intense pruritus, including those patients with abundant secretion eliminated at the end of the cures. 18 months after having finished the treatment with ozonized oil, only one patient has presented some ailments, but no other new infection by Candida alblcans has existed.
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Comparison of the use of O3 ozonized oil in gingivostomatitis in relation to conventional treatments.
160 children suffering from gingivostomatitis, between 0 and 15 years old, were treated. The clinical symptoms of these children were fever, anorexia, salivation, gingival pain and restlessness with several days of evolution.
The experimental group (60 children) was treated daily with embrocations of ozonized oil and the control group were treated with 3 different products (following the same methodology as the experimental group): Iodoxuridine (60 children), Hibitane (20 children), Boroglicerine (20 children).
The total cure of lesions in 75 % of the patients treated with ozonized oil was achieved between the third and the seventh day of treatment, with significant differences (p < 0.001) in regards to different control treatments analyzed in identical period of time.
The use of ozonized oil in the treatment of gingivostomatitis is considered very useful, due to its germicide nature, which contributes to the good evolution of these patients.
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Application of O3 ozonized cream in vulgar acne.
A preliminary study was carried out with the application of ozonized cream to fifty patients carriers of vulgar acne in different stages of evolution.
Very good results were obtained with regression of the eriteaatopustule scabby lesions. This allowed these patients to have a satisfactory result in relation to other therapies applied in this dermatosis. We consider this treatment is one more choice in the therapy for acne.
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O3 Ozone therapy in the treatment of Herpes Zoster.
An analysis of the behavior of Herpes Zoster is developed with topical application of ozonized oil and intramuscular application of ozone at a dose of 0.8 mg dally, to patients affected by such disease.
Encouraging results were obtained, a relief of local symptoms was achieved few hours after beginning the treatment with ozonized oil, with regression of the skin lesions at the fifth day of treatment.
The disappearing of the pain was achieved 24 hours after intramuscular treatment had been started, without leaving any sequels.
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O3 Ozone treatment of viral pathologies in patients of AIDS-RELATED COMPLEX (ARC).
Rosato S. Rome, Italy.
Results obtained in the treatment of a group of patients affected with AIDS related complex (ARC), suffering from various infections are shown. Secondary manifestations were mainly; Herpes (Zoster and Simplex), Micosis (specially candidiasis) and vaginal infections.
Major autohemotherapy, vaginal insufflation and application of ozone water solution were used. Results obtained are discussed.
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O3 Ozone therapy experiences in hepatic diseades: Healthy HBV carriers and chronic hepatic patients.
Pignalosa G. and Sammartino A. "Cotucho" Hospital, Naples ,Italy.
The study began in 1986, with the ozone treatment of hepatic infections caused by: B virus; NANB (nowadays C) and delta reinfections. 84 patients, 24 of them were healthy chronic carriers of B virus, and 60 were chronic hepatic patients.
Several markers of infection and laboratory tests of hepatic function have been the control parameters.
Patients have been divided in 3 groups: a) 21 cases (5 healthy carriers and 16 chronic hepatic patients) treated with interferon. b) 40 cases (12 healthy carriers and 28 chronic hepatic patients) treated with ozone, c) 23 cases treated with both interferon and ozone. Results are discussed, which were optimal.
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Exsanguineous-transfusion with O3 ozone in patients with generalized sepsis.
A sample of 15 patients, both males and females, between the ages of 25 and 50, hospitalized in intensive and intermediate units care and burned wards, who presented a generalized sepsis with multivisceral deficiency was studied. These patients had an exsanguineous-transfusion with 100 and 200 mL of ozone, with a gas concentration of 50 mg/L.
Twelve of them improved their general conditions: decrease of fever, better tissue oxygenation (verified by gasometry), as well as the negativization of blood cultures.
The three left, though at the slight improved, died afterwards, due to their critical clinical symptoms, which they presented since the beginning.
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Effect of O3 ozone therapy in critical patients submitted to hemodynamical study.
With the objective of evaluate the application of ozone therapy in critical patients, 10 mg of ozone was administered daily, by autohemotherapy, to 9 of these patients.
A complete study of hemodynamical parameters was performed, by means of Swan Canz catheter and a computer, in order to measure the cardiac output. Measures before autoheootherapy and 15 and 60 min. after it were carried out. Among the treated patients, the following results were obtained:
Increase in arterial oxygen content and in oxygen transport in approximately a 70 %; increase in oxygen consumption in approximately a 50 %; decrease in shunt fraction in approximately a 60 % after 15 min. of treatment and a 50 % after 1 h.
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O3 Ozone therapy in severe respiratory infections.
Aware of the therapeutic applications of this gas as a germicidal agent, a study in patients who suffered from respiratory diseases, due to anaerobic germs, typical mycobacteries and pseudomones resistant to habitual antibiotic therapy was carried out.
Ozone therapy was applied through autohemotherapy, with daily ozone dosage of 5 mg, for a total of 15 treatments. At the beginning and at the end of the treatment each patient was studied by X-Ray of thorax and bacteriological and mycological sputum.
The importance and efficacy of ozone therapy in respiratory diseases resistant to the traditional therapy was proved.
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O3 Ozone therapy in the field of orthopedia. Its application in open fractures.
Taking into account the great complications caused by open fractures, as the local and general infections, as well as the inability, which can be caused, this research was carried out with the aim to prevent or eradicate the infection in cases where it was already established.
Ozone therapy was applied to 45 patients with open fractures. A control groups treated with conventional procedures was used for comparison.
Some patients which received ozone therapy (experimental group) did not need any sort of antibiotic therapy.
This therapeutic method applied prophylactically, lead to a decrease in the infection levels, which are so frequent in this entity. No complications, due to osteomyelitis was observed in any case, although it was presented in the control group.
The early healing of lesions with stimulation of granulation and epithelisation tissue was observed, what lead to a faster recovery in the experimental group.
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Experience in the use of intra-atricular O3 ozone therapy. Preliminary study.
Experiences are presented related to the treatment by means of intrarticular ozone application in carriers of diseases acquired in the knee, such as condrogeneratives and in different articulations of the body, as well as in Plantar Fascitis.
Pain relief and improvement of limitations in articular movements and associated muscular spasm are reported, showing the wide therapeutical possibilities offered by this treatment.
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Medical application of ozone therapy on arthrosis.
A study with intra-muscular ozone therapy was performed covering more than 200 patients with diagnosis of arthrosis complaining of osteomyoarticular pain and associated disorders. The treatment comprised of twenty 0.8 mg injections, daily during the first ten days and on alternate days the remaining 10.
The, results obtained showed that the painful symptoms either decreased or disappeared in 95 % of patients treated. Graphics and tables showing the effects of the treatment as to pain levels is included in the study. Discussion of results and evolution after the first cycle, comprising incidence of relapse and subsequent treatment is also included.
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Evidence of O3ozone therapy in rheumatoid arthritis.
The treatment of patients with rheumatoid arthritis (RA) is a challenge for rheumatologists. Several clinical studies have shown that anti-malarial agents, gold salts, Methrotrexate and some cytotoxic agents have disease modifying properties, but response to treatment with these drugs is variable and a certain proportion of the RA patients do not benefit.
O3 / O2 has a potent inmunomodulating capability for selective modulation of subpopulations of inmunocompetent cells. These properties suggested that ozone should be useful for treatment of RA.
Clinical efficacy was observed one month after the beginning of treatment, was well established after many month of therapy, and remained stable for the remainder of one-year treatment period.
It is known that ozone administration in different application forms for the time between 6 to 8 weeks cause improvement of general condition in patients (clinically and biochemically).
Concluded that ozone is clinically effective for the treatment of patients with refractory RA, but its value for intervention therapy is limited.
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Preliminary experience in the use of ozone in rheumatoid.
In this work a preliminary report of the results obtained with the application of ozone by different ways of administration, as a therapy for Rheumatoid Arthritis, is presented. Different parameters, which measure the activity of the disease are evaluated in comparison with other schemes of treatment.
Results are discussed, showing the benefits of ozone therapy.
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Application of O3 ozone therapy in the treatment of hyperlipidemies.
Talking as a basic point the results of a previous work, 17 patients (8 males and 9 females) were studied, the aforementioned patients presented different types of hyperlypidemy.
All of them were studied before beginning the treatment on a lipid basis; later on they received 10 sessions of autohemotherapy with 5 mg of ozone, along with a dally intake of 400 mg of vitamin E. At the end of the treatment and after 7 days they were studied again.
In the female group a decrease in cholesterol (60.8 mg/dL) and in triglycerides (38.4 mg/dL) values was obtained.
In the male group, cholesterol decreased to 39.2 mg/dL and triglycerides 28.7 mg/dL.
These decreases were statistically significant, above all in the female group. The patients have been observed during 9 months after having received the treatment, they have kept lipid figures similar to those values they had after the ozone therapy.
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Treated of obliterant arteriopathies with O3 ozone using four different administration techniques.
Mattassi R. Vascular Surgery Division, "Santa Corona" Garbagnate Milanese Hospital, Milan, Italy.
Since the introduction of ozone in the therapy of obliterant arteriopathies of lower limbs, different methods of ozone administration have been proposed. Intra-arterial injection has been one of the most used, until the past few years, when the big autohemotransfusion began to be more frequently practiced.
Also certain success has been achieved with intramuscular infections, while rectal insufflation, propose by Auburg, 40 years ago, now is practically discarded. Actually the selection of one of them is not based in clinical or experimental data, but only in personal preference.
In order to assess the effects of different ozone administration ways and to compare them, a study was performed comprising 80 patients, divided in 4 groups of 20 each one.
The first group received a cycle of ozone therapy by big autohemotransfusion, the second one by intra-arterial injection, the third one by intramuscular injection and the last one by rectal insufflation. Results are presented and discussed.
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O3 zone therapy in patients with diabetic foot.
The effect of ozone therapy (local and by autohemotherapy) in patients with different kinds of diabetic foot was studied.
The disappearing of symptoms, the healing of lesions and time of stay in hospital are evaluated. Better results in cases of neuro-infectious diseases lesions were obtained.
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Therapeutical assay with O3 ozone in patients suffering from migraine.
A group of 60 patients suffering from classical or common migraine, considered severe and incapacitating, was studied. They did not respond to conventional treatment previously applied. All of them went through electrophysiological and neurobiochemical studies before the ozone treatment.
Three months later, clinical-neurobiochemical and electrophysiological control was carried out, which showed that 80 % of patients improved in one or, more clinical parameters of pain.
A decrease of the levels of neurotransmiitters in some of the patients studied was found. No electrophysiological variations were verified in patients under the ozone treatment.
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Application of O3 ozone therapy in patients with sickle cell anemia.
In Sickle cell anemia, genetic disease characterized by the sickle shape of erythrocytes in blood poor in oxygen. Is present a modified hemoglobin HBS due to the exchange in the chain of aminoacids of Glutamic acid through Valine. The cristalization or intracelular polymerization of the molecules of HBS occurs when these cells are deprived of oxygen or with a parcial pressure of oxygen (P02) very low.
In these conditions the erythrocytes lose elasticity and shape, increasing viscosity in the blood. This conveys to a reduction of the availability of oxygen in the cells, producing the vessel occlusive crisis, infarctions, abdominal or muscular pains, ulcer, etc.
This process can be reversible in the first stages since when it reoxygenates the HBS, the distortion of the cell disappears, obtaining again its normal aspect. The longer the period of flue necessary for the reoxygenation of the molecules of HBS, the larger number of red cells will die. Therefore the partial pressure of oxygen and the speed with which it is reestablished are determining factors for the symptoms to diminish and disappear.
Currently, there is no effective treatment established for this disease. On the basis of some therapeutic properties of ozone, concerning the increase of the capacity of absorption of oxygen in the erythrocytes, the disagregation of these and others, an evaluation about the effectiveness of this treatment and the prevention and (or) evolution of the vessel occlusive crisis was made. In the sickle cell anemia patient, through different ways of administration and in diverse doses.
In comparison with control group, a reduction was obtained in the time of evolution of crisis, as well as in frequency and severity. Besides, some hematologycal parameters are studied during the course of treatment.
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Source: Ozone Research Center
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